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ID AN00181569-19861200-1002
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タイトル ALTERNATIVE SYNTHESIS OF THE END DISACCHARIDE OF THE SPECIFIC PHENOLIC GLYCOLIPID I ANTIGEN FROM MYCOBACTERIUM LEPRAE AND OTHER PARTIALLY MODIFIED DISACCHARIDES
著者
藤原 剛 (Fujiwara tsuyoshi)
教養部
和泉 真蔵 (izumi shinzo)
教養部
publisher
出版地 奈良
出版者 奈良大学
上位タイトル
奈良大学紀要 (Memoirs of the Nara University). Vol.15号, (1986. 12) ,p.8- 15
識別番号
ISSN
03892204
抄録 A simpler, more productive variation on the previously described [Infect. Immun., 43, 245(1984)]synthesis of the haptenic non-reducing-end disaccharide
of phenolic glycolipid I of Mycobacterium leprae is described. Benzyl 2,3-O-is opropylidene-4-O-(3-O-methyl-2,4-di-O-acetyl-6-O-trityl-,β-D-glucopyranosy1)-α-L-rhamnopyranoside, synthesized as described previously, was de-tritylated and de-isopropylidenated, and methylated with diazomethane/BF3-etherate to give mostly the benzyl 2,3-di-O-methyl-4-O-(2,4-di-O-acetyl-3,6-di-O-methyl-β-D-glucopyranosy1)-α-L-rhamnopyranoside, but also some benzyl 2,3-di-0-methyl-4-0-(2,6-di-0-acety1-3,4-di-0-methy1-β-D-glucopyranosy1)-α-L-rhamnopyranoside, due to acetyl migration. Likewise, benzyl 2,3-O-isopropylidene-4-0-(2,4,6-tri-0-acety1-3-0-methy1-β-D-glucopyranosyl)-α-L-rhamnopyranoside upon de-isopropylidenation and methylation yielded benzyl 2,3-
di-0-methyl-4-0-(2,4,6-tri-0-acety1-3-0-methy1-β-D-g1ucopyranosy1)-α-L-rhammopyranoside. Deacetylation and hydrogenolysis of these disaccharide derivatives yielded unblocked disaccharides which are suitable precursors of neoglycoonjugates to be used in the serodiagnosis of leprosy and probing the molecular requirements for antibody binding and immunogenesity.
言語
eng
資源タイプ text
ジャンル Departmental Bulletin Paper
Index
/ Public / 奈良大学紀要 / 15号
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